Viruses & Human Cancer

Cover of: Viruses & Human Cancer |

Published by John Wiley & Sons .

Written in English

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  • Oncology,
  • Clinical & Internal Medicine,
  • Medical / Nursing

Edition Notes

Book details

ContributionsGeorge Klein (Editor), William A. Haseltine (Editor), Robert C. Gallo (Editor)
The Physical Object
Number of Pages552
ID Numbers
Open LibraryOL9547423M
ISBN 100471629286
ISBN 109780471629283

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In addition, the book covers the individual aspects of seven oncogenic viruses, i.e., hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes virus, and Merkel cell polyomavirus, and the related human cancers.

Viruses and Human Cancer provides a comprehensive review of the seven currently known human tumor viruses and their associated cancers with an emphasis on epidemiology, clinicopathologic features, and pathogenesis. Chapters are written by internationally recognized experts and all are generously illustrated with tables, diagrams and photographic images.

About this book Viruses and Human Cancer provides a comprehensive review of the seven currently known human tumor viruses and their associated cancers with an emphasis on epidemiology, clinicopathologic features, and pathogenesis.

Introduction. Viruses and Human Cancer provides a comprehensive review of the seven currently known human tumor viruses and their associated cancers with an emphasis on epidemiology, clinicopathologic features, and pathogenesis.

Chapters are written by internationally recognized experts, and all are generously illustrated with tables, diagrams, and photographic images. Human Papillomavirus (HPV) HPV are small non-enveloped DNA tumor viruses that commonly cause benign papillomas or warts in humans.

Persistent infection with high-risk subtypes of human papillomavirus (HPV) is associated with the development of cervical cancer [].HPV infects epithelial cells, and, after integration in host DNA, the production of oncoproteins, mainly E6 and E7, disrupts natural Cited by: Researchers know that there are several viruses that can lead to cancer.

For example, the human papillomavirus (HPV) can cause cervical and several other cancers. And hepatitis C can lead to liver cancer and non-Hodgkin’s lymphoma. Studying viruses and cancer is helping researchers develop vaccines and other ways to reduce cancer : Kellie Bramlet Blackburn.

The viruses that cause measles, polio, herpes and the common cold are being genetically engineered to fight certain agressive cancers. To date, seven viruses -EBV, KSHV, high-risk HPV, MCPV, HBV, HCV and HTLV1- have been consistently linked to different types of human cancer, and.

Other viruses can rapidly cause death. You will contract many viruses throughout your lifetime--and chances are you have already contracted one or more types of common human viruses. Rhinoviruses. The U.S. Centers for Disease Control and Prevention (CDC) states more than Viruses & Human Cancer book can cause the common cold--and rhinoviruses lead the pack 1 4 5.

As already noted, tumor viruses not only are important as causes of human disease but have also played a critical role in cancer research by serving as models for cellular and molecular studies of cell transformation. The small size of their genomes has made tumor viruses readily amenable to molecular analysis, leading to the identification of viral genes responsible for cancer induction and paving the way to our current understanding of cancer.

Summary: This study focuses on human cancer, an expanding field with new evidence of a wider role for viruses. It first describes the foundations of modern tumour virology before considering, in detail, various viruses and their relationships with human cancers.

Browse book content. About the book. Search in this book. Search in this book. Browse content Table of contents. Viruses and cancer. Pages Select Human immunodeficiency virus. Book chapter Full text access. Human immunodeficiency virus. Pages Viruses and Human Cancer provides a comprehensive review of the seven currently known human tumor viruses and their associated cancers with an emphasis on.

The author was among the first scientists to reveal the cervical cancer-inducing mechanisms of human papilloma viruses and isolated HPV16 and HPV18, and, as early aspublished the hypothesis that wart viruses play a role in the development of this type of cancer.

Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field.

The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author. An oncovirus is a virus that can cause term originated from studies of acutely transforming retroviruses in the –60s, when the term "oncornaviruses" was used to denote their RNA virus origin.

With the letters "RNA" removed, it now refers to any virus with a DNA or RNA genome causing cancer and is synonymous with "tumor virus" or "cancer virus". Viruses can lead to cancer by associating with host proteins, proliferating when the human immune system is weakened, and hijacking proliferating human cells.

Compared to other viruses, human tumor viruses are unusual because they infect, but do not kill, their host cells. This allows human tumor viruses to establish persistent infections. Viruses (ISSN ; CODEN: VIRUBR) is a peer-reviewed open access journal of virology, published monthly online by MDPI.

The American Society for Virology (ASV), the Spanish Society for Virology (SEV), the Canadian Society for Virology (CSV), the Italian Society for Virology (SIV-ISV), the Australasian Virology Society (AVS) and more societies are affiliated with Viruses and their members.

Written by Tina M. John 18 December, Human viruses cause a variety of maladies, depending on the virus type and the tissues infected. All humans contract multiple viruses throughout the. A Contagious Cause is the first book to trace the century-long hunt for a human cancer virus in America, an effort whose scale exceeded that of the Human Genome Project.

The government’s campaign merged the worlds of molecular biology, public health, and military planning in the name of translating laboratory discoveries into useful medical. The role of viruses in the etiology of human oral cancer is critically reviewed.

Available evidences show a positive correlation for human oral cancer with human papilloma virus (HPV), herpes. Purchase Viruses, Cell Transformation, and Cancer, Volume 5 - 1st Edition.

Print Book & E-Book. ISBN   Where viruses and bacteria cause cancer. Strictly speaking, cancer is not contagious. But a fair number of cancers are clearly caused by viral or bacterial infections: lymphomas can be triggered by the Epstein-Barr virus, which also causes mononucleosis.

Liver cancers can be caused by Hepatitis B and C. Cervical cancers can be caused by human papillomavirus, the major reason.

Cirrhosis can lead to liver cancer. Human herpes virus 8 (HHV-8). This virus is spread mostly through sexual contact. While it does not cause symptoms in most people who have it. In the 34 years since the isolation of Epstein-Barr virus there has been an accumulation of evidence linking some important human cancers and viruses.

This book describes the molecular biology and pathogenesis of these viruses, including those only recently associated with human cancers. It provides an up-to-date account of the progress in our knowledge of the virus/host interactions which. Vaccines have been developed against some cancer viruses including hepatitis B and human papillomaviruses (HPV) 16 and Multiple treatments are required and in the case of HPV 16 the vaccine does not protect against other forms of the virus.

A biological virus (whether it is a true virus, an endogenous retrovirus, or a transposon) can literally lay dormant in a word document as a string of As, Ts, Cs, and Gs. In other words, viruses. Viruses are responsible for 20% of malignant conditions in humans, including some of the most common cancers worldwide, and are especially common in immunosuppressed patients.

The identification of. (, July 13). Viruses revealed to be a major driver of human evolution: Study tracking protein adaptation over millions of years yields insights relevant to fighting today's viruses. Viruses may contribute to the development of human tumors by different mechanisms: indirectly by inducing immunosuppression or by modifying the host cell genome without persistence of viral DNA; directly by inducing oncoproteins or by altering the expression of host cell proteins at the site of viral DNA integration.

Human cancers associated with papillomavirus, hepatitis B virus, Epstein-Barr. Viruses accepted to cause human cancers include some genotypes of human papillomavirus, hepatitis B virus, hepatitis C virus, Epstein–Barr virus, Kaposi's sarcoma-associated herpesvirus and human T-lymphotropic virus.

The most recently discovered human cancer virus is a polyomavirus (Merkel cell polyomavirus) that causes most cases of a rare. The orthodoxy held that SV40 didn't cause human cancers. Emboldened by a NEJM paper that found DNA “footprints” of SV40 in childhood brain tumours, Carbone tested human mesothelioma tumour biopsies at the National Cancer Institute: 60% contained SV40 DNA.

In most, the monkey virus was active and producing proteins. It was only in that a virologist named Harald zur Hausen identified the human papillomavirus, one of the first viruses known to lead to human cancer.

From to. Five viruses are being added to the Report on Carcinogens. All ive are being listed as. known to be human carcinogens, based on suicient evidence from human studies. They all have been linked to cancer in humans. The viruses being added are: • Human immunodeiciency virus type 1 (HIV-1) • Human T-cell lymphotropic virus type 1 (HTLV-1).

Human papilloma viruses (HPVs) - a common group of viruses known to cause cervical cancers—may also have a causal role in prostate cancer, according to a. Nearly 10 percent of the human genome is made of bits of virus DNA. For the most part, this viral DNA is not harmful. In some cases, scientists are finding, it actually has a beneficial impact.

Finally, human T lymphotropic virus type 1 leads to a rare tumor, adult T-cell leukemia/lymphoma, in the Far East and the Caribbean basin, as well as to some nonneoplastic diseases. “It used to be a job to convince people that viruses were an important part of the cancer story.

There had been a lot of research, but people just didn’t. For researchers at smaller laboratories, isolating and cultivating candidate human cancer viruses was among the most expensive barriers to joining the search.

James Grace, the director of Roswell Park and an advisor to the Program, collected and cultured samples of possible cancer viruses for further study and distribution.

This last virus, the Mimivirus, described in the book's epilogue, is in fact a virus of amoebae that has changed some of the definitions of viruses because of its large size, genomic complexity, ability to encode parts of the protein translation machinery, and its own viral parasite—all properties previously thought solely within the realm of.

Other viruses, such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV), may increase a person’s risk of developing cancer by affecting the body’s immune system. In most cases, specific viruses only affect specific cells in the body, such as common cold viruses that impact the lining of the nose and throat.

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